The London groups clash within the late kick-off at Stamford Bridge.
Chelsea might be with out new first-choice goalkeeper, Emiliano Martinez, who underwent surgical procedure on a fractured jaw this week.
Martinez injured himself in the course of the 2-0 win over Everton final weekend.
Martinez will be part of workforce captain Reece James on the sidelines, with the defender additionally having an operation on his knee.
Winger Jamie Gittens is one other participant that can miss the sport, as he continues to get better from an ankle drawback.
Blues boss, Xabi Alonso, has confirmed that Pep Chavarria received’t be again to face Spurs.
Emmanuel Emegha can be a doubt for the match, following a minor setback after he returned to coaching.
Spurs are set to be with out Mykhailo Mudryk, Lucas (*11*) and Savio.
They might be joined on the sidelines by long-term casualties Xavi Simons and Wilson Odobert.
